Used in Native American traditional medicine for centuries to support gut health and cleansing. Black walnut hull contains juglone, identified in Nature's Scientific Reports as the most active compound of 14 tested in its class. Published research confirmed juglone's significant activity in supporting a healthy gut environment.

Used in traditional European herbal medicine for over 2,000 years to support gut health and the body's natural cleansing process. Published research confirmed it supports a healthy inflammatory response and a healthy gut environment.

Known as the "divine tree" Pau D'Arco has been used by Amazonian indigenous cultures for centuries to support whole body cleansing and gut health. Its active compound beta-lapachone is unique to this bark. Published research confirmed its significant cleansing activity. A clinical trial specifically in women also confirmed it supports a healthy inflammatory response, with significant improvement in comfort scores.

Used in traditional medicine across Central America, South America and the Caribbean for centuries to support digestion and cleansing. Papaya is rich in papain a natural enzyme with a long history of association with digestive comfort and gut support. A 126-patient double-blind trial confirmed papaya extract significantly supports comfortable digestion.

Pumpkin seed has a long history in traditional medicine across Native American, Chinese and Ayurvedic practices used to support gut health and body cleansing. It is rich in cucurbitin, a natural compound associated with cleansing and gut support. A 12-week randomised double-blind trial specifically in postmenopausal women confirmed significant improvement in comfort, including joint comfort, with statistically significant results (p=0.030).

Formerly listed in the US Pharmacopeia and used by both Revolutionary War and Civil War army surgeons as a field medicine. Native American traditions also used butternut bark for centuries to support gut health and the body's natural cleansing process. Part of the same Juglans family as black walnut, it is traditionally associated with supporting healthy bile production and digestive function.

One of the most traded spices in history used for over 2,000 years in Ayurveda, Traditional Chinese Medicine and medieval European herbal practice. Cloves are rich in eugenol, their primary active compound, associated with cleansing and antioxidant properties. Published research confirmed eugenol's significant cleansing activity and its role in promoting a healthy inflammatory response.

Used in Native American traditional medicine for centuries to aid urinary tract health and comfort. RADI8 contains cranberry standardised to 11% proanthocyanidins, the active compounds that help maintain a healthy urinary environment by promoting normal bacterial balance in the urinary tract. A 6-month double-blind trial in 150 women confirmed cranberry's significant contribution to urinary tract comfort.

Long associated with digestive health across European and Asian traditional medicine. Apple pectin acts as a prebiotic - nourishing beneficial gut bacteria and helping maintain a healthy gut environment. NIH-indexed research confirmed it contributes to a significant increase in the gut bacteria associated with healthy estrogen metabolism in women.

Used in Pacific Northwest Native American medicine for centuries to aid gut health and cleansing. A natural source of berberine, a well-researched compound associated with healthy gut balance. Published research confirmed berberine's significant activity in promoting a healthy gut environment.

Used in Traditional Chinese Medicine for over 2,000 years. The primary natural source of berberine standardised to 5% in RADI8, the highest concentration in the formula. During menopause, gut dysbiosis contributes to bloating and brain fog. Research confirmed berberine's activity in promoting a healthy gut environment, with effects particularly notable in women.

Long associated with whole body nourishment in Native American traditional medicine. Cardiovascular health and gut balance are among the first things affected as estrogen declines during menopause. A 12-week double-blind trial in postmenopausal women aged 45-65 confirmed blueberry extract's contribution to cardiovascular wellness, while selectively nourishing beneficial gut bacteria.

Used by Native American Plains tribes for centuries. Not all Echinacea is the same E. angustifolia promotes a healthy inflammatory response more effectively than other species, confirmed in NIH-indexed research. When unwanted organisms disrupt the gut environment, immune function and emotional balance are among the first things affected. A double-blind RCT confirmed this species significantly aids emotional calm, and a trial in 153 women confirmed its contribution to immune wellness.

Used in traditional medicine across Persia, ancient Greece and Ayurveda for centuries. Rich in falcarinol confirmed in NIH-indexed research to be more potent than sulforaphane for promoting a healthy gut environment. Unwanted organisms produce waste that affects mental clarity. Falcarinol aids the body's natural process of clearing it.

A cornerstone of medieval European herbal medicine - long associated with digestive comfort and nervous system support. When unwanted organisms disrupt the gut environment, both digestive ease and emotional comfort are affected. Research on the Stachys plant family confirmed significant contributions to female comfort and a healthy gut environment.

An essential mineral with a 3,000-year history of use across traditional medicine systems worldwide. Unwanted organisms actively compete with the body for zinc depleting what the immune system needs most. Zinc glycinate is the most bioavailable form confirmed 30% superior to standard zinc sulfate. A 2025 published review confirmed zinc deficiency mirrors the same immune deterioration pattern as estrogen decline.