Long associated with whole body nourishment in Native American traditional medicine. Cardiovascular health and gut balance are among the first things affected as estrogen declines during menopause. A 12-week double-blind trial in postmenopausal women aged 45-65 confirmed blueberry extract's contribution to cardiovascular wellness, while selectively nourishing beneficial gut bacteria.

Known as the "divine tree" Pau D'Arco has been used by Amazonian indigenous cultures for centuries to support whole body cleansing and gut health. Its active compound beta-lapachone is unique to this bark. Published research confirmed its significant cleansing activity. A clinical trial specifically in women also confirmed it supports a healthy inflammatory response, with significant improvement in comfort scores.

Used in traditional medicine across Central America, South America and the Caribbean for centuries to support digestion and cleansing. Papaya is rich in papain a natural enzyme with a long history of association with digestive comfort and gut support. A 126-patient double-blind trial confirmed papaya extract significantly supports comfortable digestion.

Used in Native American traditional medicine for centuries to aid urinary tract health and comfort. RADI8 contains cranberry standardised to 11% proanthocyanidins, the active compounds that help maintain a healthy urinary environment by promoting normal bacterial balance in the urinary tract. A 6-month double-blind trial in 150 women confirmed cranberry's significant contribution to urinary tract comfort.

Used in Pacific Northwest Native American medicine for centuries to aid gut health and cleansing. A natural source of berberine, a well-researched compound associated with healthy gut balance. Published research confirmed berberine's significant activity in promoting a healthy gut environment.

Used in Traditional Chinese Medicine for over 2,000 years. The primary natural source of berberine standardised to 5% in RADI8, the highest concentration in the formula. During menopause, gut dysbiosis contributes to bloating and brain fog. Research confirmed berberine's activity in promoting a healthy gut environment, with effects particularly notable in women.

Used by Native American Plains tribes for centuries. Not all Echinacea is the same E. angustifolia promotes a healthy inflammatory response more effectively than other species, confirmed in NIH-indexed research. When unwanted organisms disrupt the gut environment, immune function and emotional balance are among the first things affected. A double-blind RCT confirmed this species significantly aids emotional calm, and a trial in 153 women confirmed its contribution to immune wellness.

Used in traditional medicine across Persia, ancient Greece and Ayurveda for centuries. Rich in falcarinol confirmed in NIH-indexed research to be more potent than sulforaphane for promoting a healthy gut environment. Unwanted organisms produce waste that affects mental clarity. Falcarinol aids the body's natural process of clearing it.